The science behind
Dermolivo products

At the core of the Dermolivo intimate protection line is a constant commitment to scientific research and the development of effective, safe, and natural formulations. Each active complex is the result of in-depth studies on ingredients selected for their efficacy in promoting hydration, protection, and the rebalancing of the vaginal environment. The goal is to combine the best of nature with the latest scientific evidence, offering women a concrete and innovative support for intimate well-being.

Summary of contents:

Dermolivo ingredients are supported by solid scientific evidence: EvoGold® hydrates and protects the skin and mucous membranes, while DuoLact rebalances the flora and strengthens defenses. Together, they offer a complete, natural, and validated approach to intimate health, demonstrating how science and nature can work in synergy for women’s well-being.

Dermolivo's active ingredients

The Dermolivo approach is based on a clear principle: combining the power of nature with the latest scientific evidence. Studies conducted on the selected ingredients show that the well-being of the vaginal mucosa depends on a complex balance between hydration, microbial flora, pH, and local defenses.

Evogold®

Organic extra virgin olive oil enriched with natural vitamin E acts directly on the mucous barrier, improving elasticity and hydration while soothing irritations.

Duolact

Tyndalilzed lactobacilli, lactoferrin, FOS, and GOS help rebalance the vaginal microbiota, contributing to infection prevention and maintaining a physiologically acidic environment.

Acido Ialuronico

Present in Dermolivo intimate lubricant, it is one of the most studied ingredients for its extraordinary ability to retain water and promote deep hydration of the vaginal mucosa.

The strength of the Dermolivo intimate protection line lies in its scientific foundation. Each formulation is based on in-depth studies of the ingredients and the physiology of the vaginal mucosa. The goal is to naturally protect, rebalance, and strengthen the mechanisms that maintain intimate health.

The EvoGold® complex combines the emollient and antioxidant properties of organic extra virgin olive oil with the regenerative power of natural vitamin E. This synergy improves hydration and elasticity of the vaginal mucosa, reduces dryness, and soothes irritation and redness. Its antioxidant action helps protect cells from oxidative stress, supporting the integrity of the mucous membranes.

DuoLact® was developed to rebalance and support the vaginal microbiota. Tyndalized lactobacilli help maintain an acidic pH, creating an environment hostile to pathogenic microorganisms, while lactoferrin provides natural bacteriostatic and anti-inflammatory action. The prebiotics FOS and GOS selectively nourish the beneficial flora, promoting the growth of “good” lactobacilli and restoring microbial balance.

Our Dermolivo water-based intimate lubricant also contains hyaluronic acid, one of the most studied ingredients for its extraordinary ability to retain water and promote deep hydration of the vaginal mucosa. Hyaluronic acid supports tissue regeneration and helps restore natural elasticity, making it a valuable ally in cases of vaginal dryness, atrophy, or after gynecological treatments and hormonal therapies.

Together, these actives represent the essence of the Dermolivo approach: gentle yet powerful formulations where science meets nature to offer real, validated, and safe solutions for women’s well-being.

Bibliography:

Evogold

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  2. González-Acedo A, Ramos-Torrecillas J, Illescas-Montes R, Costela-Ruiz VJ, Ruiz C, Melguizo-Rodríguez L, García-Martínez O. The Benefits of Olive Oil for Skin Health: Study on the Effect of Hydroxytyrosol, Tyrosol, and Oleocanthal on Human Fibroblasts. Nutrients. 2023 Apr 25;15(9):2077. doi: 10.3390/nu15092077. PMID: 37432217; PMCID: PMC10181161.
  3. Ruiz M.A., Arias J.L., Skin creams made with olive oil, dal testo “Olives and olive oil in health and disease prevention”, Academic Press, 2010.
  4. Passi S., De Pita’O., Puddu P., Biochimica dei lipidi cutanei, Edizione fuori commercio riservata ai medici, 2002.
  5. Badiu D., Luque R., Effect of olive oil on the skin, dal testo “Olives and olive oil in health and disease prevention”, Academic Press, 2010.
  6. Donato-Trancoso A., Monte-Alto-Costa A., Romana-Souza B., Olive oil-induced reduction of oxidative damage and inflammation promotes wound healing of pressure ulcers in mice. J. Dermatol. Sci.
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Duolact

  1. Orsi, N. The antimicrobial activity of lactoferrin: Current status and perspectives. Biometals 2004, 17, 189–196. [CrossRef].
  2. Baker, H.M.; Baker, E.N. Lactoferrin and iron: Structural and dynamic aspects of binding and release. Biometals 2004, 17, 209–216. [CrossRef] [PubMed].
  3. YueHanQing-lingRen Does probiotics work for bacterial vaginosis and vulvovaginal candidiasis – Current Opinion in Pharmacology Volume 61, December 2021, Pages 83-90.
  4. Sessa, R.; Di Pietro, M.; Filardo, S.; Bressan, A.; Mastromarino, P.; Biasucci, A.V.; Rosa, L.; Cutone, A.; Berlutti, F.; Paesano, R.; et al. Lactobacilli-lactoferrin interplay in Chlamydia trachomatis infection. Pathog. Dis. 2017, 75. [CrossRef].
  5. Naidu, A.S.; Miedzobrodzki, J.; Musser, J.M.; Rosdahl, V.T.; Hedstrom, S.A.; Forsgren, A. Human lactoferrin binding in clinical isolates of Staphylococcus aureus. J. Med. Microbiol. 1991, 34, 323–328. [CrossRef].
  6. Superti, F.; Berlutti, F.; Paesano, R.; Valenti, P. Structure and activity of lactoferrin-a multi functional protective agent for human health. In Iron Metabolism and Disease; Fuchs, H., Ed.; Publisher Research Signpost: Trivandrum, India, 2008; Volume 8, pp. 1–32.
  7. Lupetti, A.; Paulusma-Annema, A.; Welling, M.M.; Dogterom-Ballering, H.; Brouwer, C.P.; Senesi, S.; Van Dissel, J.T.; Nibbering, P.H. Synergistic activity of the N-terminal peptide of human lactoferrin and fluconazole against Candida species. Antimicrob. Agents Chemother. 2003, 47, 262–267. [CrossRef] [PubMed].
  8. Andres, M.T.; Viejo-Díaz, M.; Fierro, J.F. Human lactoferrin induces apoptosis-like cell death in Candida albicans: Critical role of K+-channel-mediated K+ efflux. Antimicrob. Agents Chemother. 2008, 52, 4081–4088. [CrossRef].
  9. Nasopoulou C., Karantonis H.C., Detopoulou M., Demopoulos C.A., Zabetakis I., Exploiting the anti-inflammatory properties of olive (Olea europaea) in the sustainable production of functional food and neutraceuticals, Phytochem, Rev. 2014, 13, 445–458.
  10. Russo R.; Iosi F.; Superti F.; Lactobacilli and lactoferrin: Biotherapeutic effects for vaginal health. Journal of Functional Foods 45 (2018) 86–94 (Elsevier).
  11. The pathogenesis of BV and VVC and the potential mechanism of probiotics for the prevention and treatment of BV and VVC. BV, bacterial vaginosis; VCC, vulvovaginal candidiasis – Current Opinion in Pharmacology 2021, 61:83–90.

 

Hyaluronic Acid

  1. Sanchez-Prieto M, Pingarrón C, Bergamaschi L, Bermúdez JC, Subiris González J, Sánchez Sánchez R, Poyo Torcal S, Gómez M, Ruiz Pérez ML, Castillo Martínez M, Peña Penedo ME, Sánchez-Borrego R. Prospective, multicenter, uncontrolled study on the effectiveness and safety of a hyaluronic acid water-based vaginal lubricant in alleviating vaginal dryness and dyspareunia. Gynecol Endocrinol. 2024 Mar 5;40(1):2317268. doi: 10.1080/09513590.2024.2317268. Epub 2024 Mar 12. PMID: 38468593.
  2. Jafarzade A, Mungan T, Aghayeva S, Yildirim Baydemir B, Ekiz OU, Biri A. A comparison of hyaluronic acid and estradiol treatment in vulvovaginal atrophy. Eur Rev Med Pharmacol Sci. 2024 Jan;28(2):571-576. doi: 10.26355/ eurrev 202401 35054. PMID:38305601.
  3. Dos Santos CCM, Uggioni MLR, Colonetti T, Colonetti L, Grande AJ, Da Rosa MI. Hyaluronic Acid in Postmenopause Vaginal Atrophy: A Systematic Review. J Sex Med. 2021 Jan;18(1):156-166. doi: 10.1016/j.jsxm.2020.10.016. Epub 2020 Dec 5. PMID: 33293236.